Dr. Baker was the first to identify TP53 mutations in human cancer. Focusing on pediatric gliomas, she also co-discovered the first histone mutations in human cancer, illuminating critical connections between development, epigenetics and cancer. This research provided clear evidence that pediatric high grade gliomas are distinct from adult high grade gliomas. Dr. Baker is a Member of the St. Jude Children’s Hospital Faculty and Endowed Chair in Brain Tumor Research. She serves as the Director of St. Jude's Brain Tumor Research Division, Associate Director of Basic Research at St. Jude's Comprehensive Cancer Center, and Co-Leader of Neurobiology and Brain Tumor Program. Dr. Baker was also recently appointed Associate Dean, Ph.D. Program in Biomedical Sciences at the St. Jude Children's Research Hospital Graduate School of Biomedical Sciences.