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Xi Huang, Ph.D
The Hospital for Sick Children
2018 Sontag Award Recipient
"The Sontag Foundation Distinguished Scientist Award supports my work defining ion channel functions in brain cancer. We believe this work will lead to the development of novel therapeutics for patients."
About DSA-Funded Research
The Hu Lab studies physical properties and mechano-electrical-chemical signaling in cancer. While extensive research has informed genetics and biochemical mechanisms in tumorigenesis, how mechanical and electrical signaling regulate cancer is less defined. Ion channels govern cell behaviors by perceiving physicochemical cues (mechanical force, membrane voltage, temperature, pH etc.) to control ion flux across membranes. Using multi-disciplinary approaches in bioinformatics, Drosophila and mouse genetics, xenograft modeling, advanced imaging, electrophysiology, and bioengineering, they discover disease mechanisms and therapeutic vulnerabilities at the interface of cancer biology, neuroscience, and mechanobiology.
Canada Research Chair; Cancer Biophysics
Senior Scientist; Developmental & Stem Cell Biology Program, The Hospital for Sick Children
Senior Scientist; Arthur & Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children
Assistant Professor; Department of Molecular Genetics, University of Toronto