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Brain tumors are the leading cause of cancer-related deaths in children. Moreover, patients with aggressive brain tumors such as DMG/DIPG have a 5-year survival rate of only 2%. While the cellular machinery for signaling, growth and epigenetic modifications is characterized, the enzymes required to produce the metabolic co-factors essential for these epigenetic modifications (Histone, RNA and DNA) are poorly understood. To address this knowledge gap, we hypothesize that DIPG cells use one-carbon metabolism to promote growth, by altering the epigenome (DNA) and the epitranscriptome (RNA) by production of novel oncometabolites. Using innovative models, and emerging metabolomic techniques, we will interrogate the role of methionine metabolism on glioma growth. If our hypothesis is correct, we envision targeting metabolism (by dietary intervention or small molecule inhibitors) becoming a mainstay therapy in brain tumors.