"The Sontag Foundation provided my lab with critical funding to explore the fundamental principles of how IncRNAs work in normal cells, so we can understand why their disruption leads to various human cancers and utilize this knowledge to develop specific therapeutics in cancer treatment."

About DSA-Funded Research

Over the past decade, it has become clear that mammalian genomes encode thousands of long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological processes. The Guttman lab aims to understand the mechanisms by which lncRNAs act to control cellular functions. Specifically, they aim to understand how lncRNAs can regulate gene expression by coordinating regulatory proteins, localizing to genomic DNA targets, and shaping three-dimensional (3D) nuclear organization.