"The Sontag Foundation provided my lab with critical funding to explore the fundamental principles of how IncRNAs work in normal cells, so we can understand why their disruption leads to various human cancers and utilize this knowledge to develop specific therapeutics in cancer treatment."
About DSA-Funded Research
Over the past decade, it has become clear that mammalian genomes encode thousands of long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological processes. The Guttman lab aims to understand the mechanisms by which lncRNAs act to control cellular functions. Specifically, they aim to understand how lncRNAs can regulate gene expression by coordinating regulatory proteins, localizing to genomic DNA targets, and shaping three-dimensional (3D) nuclear organization.
Professor, Division of Biology and Biological Engineering, Caltech
Associate Director, UCLA-Caltech Medical Scientist Training Program (MD-PhD program)
Robertson Investigator, New York Stem Cell Foundation
Investigator, Heritage Medical Research Institute
University of Pennsylvania, B.A., Molecular Biology and Computational Biology
University of Pennsylvania, Masters of Biotechnology in Computational Biology and Bioinformatics
Massachusetts Institute of Technology, Ph.D., Biology