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Dr. Johnson's laboratory has focused on understanding mechanisms of programmed cell death occurring in the nervous system after injury, in oncogenesis and in neurodegenerative disorders. His research combines mRNA microarray and mass spectrometry proteomics with other cell and molecular biology techniques to examine cell death pathways activated by various forms of injury in mouse neurons or glia, or in primary human glioma cells. Once identified, proteins essential to injury-mediated programmed cell death are investigated further to elucidate their function. A better understanding of these cell death mechanisms may lead to the development of more effective therapies for the treatment of brain tumors or nervous system injury.