Hello, you are using an old browser that's unsafe and no longer supported. Please consider updating your browser to a newer version, or downloading a modern browser.
Glioblastoma is one of the most aggressive forms of brain cancer, and radiation treatment is one of the only therapies that works to slow the growth of these cancer. Still, glioblastomas inevitably develop resistance to radiation and are typically fatal. The Wahl research group tries to understand how alterations in metabolism causes glioblastomas to be resistant to therapies such as radiation. They then block these metabolic pathways to try to make treatments work better. They have found that non-cancerous cells in glioblastoma tumors promote metabolism in the cancer cells, which causes radiation resistance. With the funding provided by the Sontag Distinguished Scientist Award, they will work to understand how non-cancerous cells in glioblastoma promote the metabolism of cancer cells. They will then interrupt this “metabolic communication” to improve how glioblastomas respond to treatment.