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The work in Dr. Kuo's lab centers around understanding cellular pathways regulating postnatal/adult neural stem cells, using the rodent brain as a model system. Their current focus deals with how specialized environments in the brain (also called “niches”) sustain production of new neurons in vivo; how these microenvironments are changed in response to circuit-level inputs; and how injury modifies neural stem cell proliferation/differentiation. A better understanding of these processes may lead to future therapies for patients suffering from pre/postnatal brain injuries.