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Dr. Bhaduri's lab will explore how programs that are normally used to promote normal brain development are reactivated in glioblastoma brain tumors. To explore these questions, they will use a cortical organoid transplantation model of the cancer to investigate how the tumor microenvironment impacts the cells and their lineage. Using these new models and approaches, they hope to understand how the tumor reacts in different environments in order to predict tumor response and to devise new treatment options for patients.