Dr. Stile’s research group currently is cloning and characterizing genes that "instruct" brain progenitor cells to develop into mature neurons, astrocytes, and oligodendrocytes - the cellular components of a mature brain. They reason that the genes that give rise to a normal, functioning brain are the same genes that give rise to cancer of the brain when their expression is perturbed. Given a defined genetic target, scientists can screen large libraries of chemically diverse compounds to identify drugs that interact with the protein encoded by that specific gene. These genetically targeted “smart drugs” kill tumor cells, minimizing collateral damage to normal cells.

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Principal Positions Held

Harvard Medical School and the Dana-Farber Cancer Institute

  • Professor of Neurobiology, Harvard Medical School
  • Professor, Department of Microbiology and Molecular Genetics, 1986-present
  • Co-Chair, Cancer Biology, Dana-Farber Cancer Institute
  • Deputy Director, Mahoney Center for Neuro-Oncology, Dana-Farber Cancer Institute, 1986-present
  • Associate Professor, Department of Microbiology and Molecular Genetics, 1980-1986
  • Assistant Professor, Department of Microbiology and Molecular Genetics, 1976 - 1980
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